American Mastiffs Puppies for Sale
About the American Mastiffs
The American Mastiff is a giant guardian breed developed in Ohio by Fredericka Wagner, primarily by crossing the English Mastiff with the Anatolian Shepherd to add hardiness and reduce drooling while keeping mastiff size and temperament. The result is a massive, dignified dog with a broad head, heavy bone, and a notably calm, family-oriented disposition. American Mastiffs are typically gentle, loyal, and protective, forming deep bonds with their households and serving as steady, imposing guardians. Their enormous size demands early training, ample space, and awareness of the shorter lifespan and higher costs that come with giant breeds, but devotees prize their mellow, affectionate nature.
Every dog is an individual — genetics, socialization, health, training, and environment matter more than breed averages.
Typical tendencies
Scored against PuppyList’s editorial rubric. Tendencies, not guarantees.
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Browse all puppiesWhere this breed shines
- Calm, gentle giant devoted to family
- Drier-mouthed than many mastiffs
- Imposing yet steady natural guardian
Things to consider
- Enormous size means high food, space, and vet costs
- Shorter lifespan typical of giant breeds
- Needs early training to manage strength
History
The American Mastiff was created in the 1990s at Flying W Farms in Ohio by breeding English Mastiffs with Anatolian Shepherds, aiming for a healthier, drier-mouthed mastiff. It is recognized by the Continental Kennel Club and some rare-breed registries but not by the AKC. Breeders maintain it as a distinct line rather than a random cross.
Temperament
American Mastiffs are typically calm, gentle, and deeply loyal, forming strong family bonds and showing patience with children. They are naturally protective and watchful without unnecessary aggression when well socialized. Their size means calm, consistent training from puppyhood is essential to manage their strength safely.
Questions to ask a American Mastiffs breeder
- Are parents screened for hips, elbows, and heart conditions?
- How closely does the line follow the American Mastiff standard?
- What is the typical adult size and temperament in your dogs?
Health considerations to discuss
Hip and elbow dysplasia. Giant breeds are prone to joint disease; request OFA or equivalent clearances.
Bloat (gastric dilatation-volvulus). Deep-chested giants are at high risk; consider gastropexy and slow feeding.
Cardiac disease. Large mastiff types can develop heart conditions; ask for cardiac screening.
Informational only — always consult a veterinarian and ask breeders for documentation. Sources: AKC - Mastiff · AKC - Anatolian Shepherd Dog — written by PuppyList editorial
Questions worth asking about any American Mastiffs litter
- Can I see the puppy and its mother — in person or on a live video call?
- What health checks, vaccinations, and vet visits has this litter had?
- How was the litter raised and socialized?
- What paperwork comes with the puppy (health records, registry papers if applicable)?
- What is your deposit, payment, and pickup/transport process?
Frequently asked questions
How do I buy a American Mastiffs puppy on PuppyList?
Browse the American Mastiffs listings on this page, open one to see photos, details, and the breeder's information, then contact the breeder directly. PuppyList is a marketplace — you arrange the purchase with the breeder yourself.
How can I tell if a American Mastiffs breeder is trustworthy?
Contact the breeder, ask for recent photos or a video of the actual puppy, and confirm details before you commit. Never send money before verifying. See our listing guidelines for the full buyer-safety checklist.